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HIV-2 protease

From Wikipedia, the free encyclopedia
HIV-2 retropepsin
Identifiers
EC no.3.4.23.47
CAS no.144114-21-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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NCBIproteins

HIV-2 protease or retropepsin (EC 3.4.23.47) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction

Endopeptidase for which the P1 residue is preferably hydrophobic

This enzyme belongs to the peptidase family A2.

References

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  1. ^ Tözsér J, Bláha I, Copeland TD, Wondrak EM, Oroszlan S (April 1991). "Comparison of the HIV-1 and HIV-2 proteinases using oligopeptide substrates representing cleavage sites in Gag and Gag-Pol polyproteins". FEBS Letters. 281 (1–2): 77–80. doi:10.1016/0014-5793(91)80362-7. PMID 2015912.
  2. ^ Chen Z, Li Y, Chen E, Hall DL, Darke PL, Culberson C, Shafer JA, Kuo LC (October 1994). "Crystal structure at 1.9-A resolution of human immunodeficiency virus (HIV) II protease complexed with L-735,524, an orally bioavailable inhibitor of the HIV proteases". The Journal of Biological Chemistry. 269 (42): 26344–8. doi:10.1016/S0021-9258(18)47199-2. PMID 7929352.
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